Effect of weekly versus daily primaquine on Plasmodium vivax malaria recurrences: A real-life cohort study

Effect of weekly versus daily primaquine on Plasmodium vivax malaria recurrences: A real-life cohort study

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ABSTRACT Background: Although primaquine (PQ) is indicated for G6PD-deficient patients, data on weekly PQ use in Brazil are limited.Methods: We aimed to investigate malaria recurrences among participants receiving daily and weekly PQ treatments in a real-life setting HOME SCENT of two municipalities in the Amazon between 2019 and 2020.Results: Patients receiving weekly PQ treatment had a lower risk of recurrence than those receiving daily PQ treatment (risk ratio: 0.62, 95% confidence interval: 0.

41-0.94), using a model adjusted for study site.Conclusions: Weekly LC PQ use did not increase the risk of malaria recurrence.Further studies with larger populations are warranted.